Some documentation is known to be well out of date.
OPL3 FM is not implemented yet (but Midi, SB8 and SB16 work)
Some database programs (Clipper, FoxPro) have problems with locking in certain configurations. smbfs doesn't support locking. $_full_file_locks=(on) may or may not help.
Mortal Kombat 1 and 2 are not producing any sound for unknown reasons.
X-COM Apocalypse (DEMO version) locks up at startup if configured with sound.